PIP5K1A (Phosphatidylinositol-4-Phosphate 5-Kinase, Type I, alpha, PIP5K1A)
Short Description: Catalyzes the phosphorylation of phosphatidylinositol 4- phosphate (PtdIns4P) to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). PtdIns(4,5)P2 is involved in a variety of cellular processes and is the substrate to form phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3), another second messenger. The majority of PtdIns(4,5)P2 is thought to occur via type I phosphatidylinositol 4-phosphate 5-kinases given the abundance of PtdIns4P. Participates in a variety of cellular processes such as actin cytoskeleton organization, cell adhesion, migration and phagocytosis. Required for membrane ruffling formation, actin organization and focal adhesion formation during directional cell migration by controlling integrin-induced translocation of RAC1 to the plasma membrane. Together with PIP5K1C is required for phagocytosis, but they regulate different types of actin remodeling at sequential steps. Promotes particle ingestion by activating WAS that induces Arp2/3 dependent actin polymerization at the nascent phagocytic cup. Together with PIP5K1B is required after stimulation of G-protein coupled receptors for stable platelet adhesion. Plays a role during calcium-induced keratinocyte differentiation. Recruited to the plasma membrane by the E-cadherin/beta-catenin complex where it provides the substrate PtdIns(4,5)P2 for the production of PtdIns(3,4,5)P3, diacylglycerol and inositol 1,4,5-trisphosphate that mobilize internal calcium and drive keratinocyte differentiation. Together with PIP5K1C have a role during embryogenesis. Functions also in the nucleus where acts as an activator of TUT1 adenylyltransferase activity in nuclear speckles, thereby regulating mRNA polyadenylation of a select set of mRNAs.
More information related to gene PIP5K1A.
More information related to gene PIP5K1A.
Products related to PIP5K1A Gene:
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73 results
OriGene rc219870l1v
ORF
PExp
Lentiviral Vector
pLenti-C-Myc-DDK
Chloramphenicol
CMV Promoter
Myc-DYKDDDDK Tag
Transient
1
- Type:
- ORF
- Application:
- Protein Expression
- Gene:
- Phosphatidylinositol-4-Phosphate 5-Kinase, Type I, alpha (PIP5K1A)
- Species:
- Human
- Vector type:
- Lentiviral Vector
- Vector backbone:
- pLenti-C-Myc-DDK
- Resistance Gene:
- Chloramphenicol
- Promoter:
- CMV Promoter
- Fusion Tag:
- Myc-DYKDDDDK Tag
- Expression:
- Transient
Catalog No. ABIN6421121
$1,050.39
Plus shipping costs $50.00, if applicable $20.00 dry ice
200 μL
Shipping to:
United States
Delivery in 21 to 27 Business Days
OriGene rc219870l2v
ORF
PExp
Lentiviral Vector
pLenti-C-mGFP
Chloramphenicol
CMV Promoter
GFP tag
Transient
1
- Type:
- ORF
- Application:
- Protein Expression
- Gene:
- Phosphatidylinositol-4-Phosphate 5-Kinase, Type I, alpha (PIP5K1A)
- Species:
- Human
- Vector type:
- Lentiviral Vector
- Vector backbone:
- pLenti-C-mGFP
- Resistance Gene:
- Chloramphenicol
- Promoter:
- CMV Promoter
- Fusion Tag:
- GFP tag
- Expression:
- Transient
Catalog No. ABIN6421122
$1,050.39
Plus shipping costs $50.00, if applicable $20.00 dry ice
200 μL
Shipping to:
United States
Delivery in 21 to 27 Business Days
OriGene rc227689l2v
ORF
PExp
Lentiviral Vector
pLenti-C-mGFP
Chloramphenicol
CMV Promoter
GFP tag
Transient
1
- Type:
- ORF
- Application:
- Protein Expression
- Gene:
- Phosphatidylinositol-4-Phosphate 5-Kinase, Type I, alpha (PIP5K1A)
- Species:
- Human
- Vector type:
- Lentiviral Vector
- Vector backbone:
- pLenti-C-mGFP
- Resistance Gene:
- Chloramphenicol
- Promoter:
- CMV Promoter
- Fusion Tag:
- GFP tag
- Expression:
- Transient
Catalog No. ABIN6429432
$1,062.27
Plus shipping costs $50.00, if applicable $20.00 dry ice
200 μL
Shipping to:
United States
Delivery in 21 to 27 Business Days
OriGene rc227689l1v
ORF
PExp
Lentiviral Vector
pLenti-C-Myc-DDK
Chloramphenicol
CMV Promoter
Myc-DYKDDDDK Tag
Transient
1
- Type:
- ORF
- Application:
- Protein Expression
- Gene:
- Phosphatidylinositol-4-Phosphate 5-Kinase, Type I, alpha (PIP5K1A)
- Species:
- Human
- Vector type:
- Lentiviral Vector
- Vector backbone:
- pLenti-C-Myc-DDK
- Resistance Gene:
- Chloramphenicol
- Promoter:
- CMV Promoter
- Fusion Tag:
- Myc-DYKDDDDK Tag
- Expression:
- Transient
Catalog No. ABIN6429431
$1,062.27
Plus shipping costs $50.00, if applicable $20.00 dry ice
200 μL
Shipping to:
United States
Delivery in 21 to 27 Business Days
ORF
Clon
Gateway Cloning Vector
pDONR223
Spectinomycin
unconjugated
Catalog No. ABIN5314885
$223.79
Plus shipping costs $50.00
2 μg
Shipping to:
United States
Delivery in 15 to 19 Business Days
OriGene tl310416
shRNA
RNAi
Lentiviral Vector
pGFP-C-shLenti
Chloramphenicol
U6 Promoter
GFP tag
Transient
1
- Type:
- shRNA
- Application:
- RNA Interference
- Gene:
- Phosphatidylinositol-4-Phosphate 5-Kinase, Type I, alpha (PIP5K1A)
- Species:
- Human
- Vector type:
- Lentiviral Vector
- Vector backbone:
- pGFP-C-shLenti
- Resistance Gene:
- Chloramphenicol
- Selection Marker:
- Puromycin
- Promoter:
- U6 Promoter
- Fusion Tag:
- GFP tag
- Expression:
- Transient, Stable
Catalog No. ABIN3755618
$1,002.87
Plus shipping costs $50.00
1 kit
Shipping to:
United States
Delivery in 16 to 17 Business Days
OriGene tg310416
shRNA
RNAi
Retroviral Vector
pGFP-V-RS
Kanamycin
U6 Promoter
GFP tag
Transient
1
- Type:
- shRNA
- Application:
- RNA Interference
- Gene:
- Phosphatidylinositol-4-Phosphate 5-Kinase, Type I, alpha (PIP5K1A)
- Species:
- Human
- Vector type:
- Retroviral Vector
- Vector backbone:
- pGFP-V-RS
- Resistance Gene:
- Kanamycin
- Selection Marker:
- Puromycin
- Promoter:
- U6 Promoter
- Fusion Tag:
- GFP tag
- Expression:
- Transient, Stable
Catalog No. ABIN3735280
$707.85
Plus shipping costs $50.00
1 kit
Shipping to:
United States
Delivery in 16 to 17 Business Days
OriGene tg516250
shRNA
RNAi
Retroviral Vector
pGFP-V-RS
Kanamycin
U6 Promoter
GFP tag
Transient
1
- Type:
- shRNA
- Application:
- RNA Interference
- Gene:
- Phosphatidylinositol-4-Phosphate 5-Kinase, Type I, alpha (PIP5K1A)
- Species:
- Mouse
- Vector type:
- Retroviral Vector
- Vector backbone:
- pGFP-V-RS
- Resistance Gene:
- Kanamycin
- Selection Marker:
- Puromycin
- Promoter:
- U6 Promoter
- Fusion Tag:
- GFP tag
- Expression:
- Transient, Stable
Catalog No. ABIN3698239
$707.85
Plus shipping costs $50.00
1 kit
Shipping to:
United States
Delivery in 16 to 17 Business Days
OriGene tf310416
shRNA
RNAi
Retroviral Vector
pRFP-C-RS
Chloramphenicol
U6 Promoter
RFP tag
Transient
1
- Type:
- shRNA
- Application:
- RNA Interference
- Gene:
- Phosphatidylinositol-4-Phosphate 5-Kinase, Type I, alpha (PIP5K1A)
- Species:
- Human
- Vector type:
- Retroviral Vector
- Vector backbone:
- pRFP-C-RS
- Resistance Gene:
- Chloramphenicol
- Selection Marker:
- Puromycin
- Promoter:
- U6 Promoter
- Fusion Tag:
- RFP tag
- Expression:
- Transient, Stable
Catalog No. ABIN3714941
$874.17
Plus shipping costs $50.00
1 kit
Shipping to:
United States
Delivery in 16 to 17 Business Days
OriGene tf516250
shRNA
RNAi
Retroviral Vector
pRFP-C-RS
Chloramphenicol
U6 Promoter
RFP tag
Transient
1
- Type:
- shRNA
- Application:
- RNA Interference
- Gene:
- Phosphatidylinositol-4-Phosphate 5-Kinase, Type I, alpha (PIP5K1A)
- Species:
- Mouse
- Vector type:
- Retroviral Vector
- Vector backbone:
- pRFP-C-RS
- Resistance Gene:
- Chloramphenicol
- Selection Marker:
- Puromycin
- Promoter:
- U6 Promoter
- Fusion Tag:
- RFP tag
- Expression:
- Transient, Stable
Catalog No. ABIN3678540
$707.85
Plus shipping costs $50.00
1 kit
Shipping to:
United States
Delivery in 16 to 17 Business Days
Synonyms and alternative names related to PIP5K1A
- phosphatidylinositol-4-phosphate 5-kinase type 1 alpha (PIP5K1A)
- phosphatidylinositol-4-phosphate 5-kinase, type 1, alpha (Pip5k1a)
- phosphatidylinositol-4-phosphate 5-kinase, type I, alpha L homeolog (pip5k1a.L)
- phosphatidylinositol-4-phosphate 5-kinase, type I, alpha (pip5k1a)
- phosphatidylinositol-4-phosphate 5-kinase, type 1 alpha (Pip5k1a)
- phosphatidylinositol-4-phosphate 5-kinase, type I, alpha, a (pip5k1aa)
- phosphatidylinositol-4-phosphate 5-kinase type 1 alpha (Pip5k1a)
- phosphatidylinositol-4-phosphate 5-kinase, type I, alpha, b (pip5k1ab)
- im:7140933
- PIP5K1A
- pip5k1a
- Pip5k1b
- pip5k1b
- pip5k1c
- Pipk5a
- Pipk5b
- zgc:110576
- zgc:158838
Gene-IDs for different species
Protein level used designations for PIP5K1A
- 68 kDa type I phosphatidylinositol 4-phosphate 5-kinase alpha
- 68 kDa type I phosphatidylinositol-4-phosphate 5-kinase alpha
- PIP5K1-alpha
- PIP5KIalpha
- phosphatidylinositol 4-phosphate 5-kinase type I alpha
- phosphatidylinositol 4-phosphate 5-kinase type-1 alpha
- phosphatidylinositol-4-phosphate 5-kinase type-1 alpha
- ptdIns(4)P-5-kinase 1 alpha
- phosphatidylinositol-4-phosphate 5-kinase, type 1 beta
- phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
- phosphatidylinositol-4-phosphate 5-kinase, type I, beta
- 68 kDa type I phosphatidylinositol 4-phosphate 5-kinase
- 68 kDa type I phosphatidylinositol-4-phosphate 5-kinase
- PI4P5K-I[a]
- PI4P5KIbeta
- phosphatidylinositol 4-phosphate 5-kinase type I beta
- phosphatidylinositol-4-phosphate 5-kinase type I alpha
- phosphatidylinositol-4-phosphate 5-kinase type I beta
- phosphatidylinositol-4-phosphate 5-kinase type-1 gamma
Proteomics products related to PIP5K1A Gene
Other products related to PIP5K1A such as antibodies, ELISA kits and high-purity proteins are available on our partner website antibodies-online.com
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