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PIP5K1A (Phosphatidylinositol-4-Phosphate 5-Kinase, Type I, alpha, PIP5K1A)

Short Description: Catalyzes the phosphorylation of phosphatidylinositol 4- phosphate (PtdIns4P) to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). PtdIns(4,5)P2 is involved in a variety of cellular processes and is the substrate to form phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3), another second messenger. The majority of PtdIns(4,5)P2 is thought to occur via type I phosphatidylinositol 4-phosphate 5-kinases given the abundance of PtdIns4P. Participates in a variety of cellular processes such as actin cytoskeleton organization, cell adhesion, migration and phagocytosis. Required for membrane ruffling formation, actin organization and focal adhesion formation during directional cell migration by controlling integrin-induced translocation of RAC1 to the plasma membrane. Together with PIP5K1C is required for phagocytosis, but they regulate different types of actin remodeling at sequential steps. Promotes particle ingestion by activating WAS that induces Arp2/3 dependent actin polymerization at the nascent phagocytic cup. Together with PIP5K1B is required after stimulation of G-protein coupled receptors for stable platelet adhesion. Plays a role during calcium-induced keratinocyte differentiation. Recruited to the plasma membrane by the E-cadherin/beta-catenin complex where it provides the substrate PtdIns(4,5)P2 for the production of PtdIns(3,4,5)P3, diacylglycerol and inositol 1,4,5-trisphosphate that mobilize internal calcium and drive keratinocyte differentiation. Together with PIP5K1C have a role during embryogenesis. Functions also in the nucleus where acts as an activator of TUT1 adenylyltransferase activity in nuclear speckles, thereby regulating mRNA polyadenylation of a select set of mRNAs.
More information related to gene PIP5K1A.

Products related to PIP5K1A Gene:

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73 results

Rat PIP5K1A shRNA in Lentiviral Vector (GFP tag)
OriGene tl703682 shRNA RNAi Lentiviral Vector pGFP-C-shLenti Chloramphenicol U6 Promoter GFP tag Transient
Type:
shRNA
Application:
RNA Interference
Gene:
Phosphatidylinositol-4-Phosphate 5-Kinase, Type I, alpha (PIP5K1A)
Species:
Rat
Vector type:
Lentiviral Vector
Vector backbone:
pGFP-C-shLenti
Resistance Gene:
Chloramphenicol
Selection Marker:
Puromycin
Promoter:
U6 Promoter
Fusion Tag:
GFP tag
Expression:
Transient, Stable
Catalog No. ABIN3511839
$1,002.87
Plus shipping costs $50.00
1 kit
Shipping to: United States
Delivery in 16 to 17 Business Days
Details
Details
Mouse PIP5K1A CRISPR gRNA + Cas9 in Mammalian Expression Vector (Myc-DYKDDDDK Tag)
OriGene kn513322 gRNA + Cas9 GEEN Mammalian Expression Vector pCas-Guide Ampicillin U6 Promoter Myc-DYKDDDDK Tag Transient
Type:
gRNA + Cas9
Application:
Genome Editing with Engineered Nucleases
Gene:
Phosphatidylinositol-4-Phosphate 5-Kinase, Type I, alpha (PIP5K1A)
Species:
Mouse
Vector type:
Mammalian Expression Vector
Vector backbone:
pCas-Guide
Resistance Gene:
Ampicillin
Promoter:
U6 Promoter, Enhanced CMV Promoter
Fusion Tag:
Myc-DYKDDDDK Tag
Expression:
Transient
Catalog No. ABIN3230753
$1,640.43
Plus shipping costs $50.00
1 kit
Shipping to: United States
Delivery in 21 to 22 Business Days
Details
Details
Human PIP5K1A CRISPR gRNA + Cas9 in Mammalian Expression Vector (Myc-DYKDDDDK Tag)
OriGene kn419870 gRNA + Cas9 GEEN Mammalian Expression Vector pCas-Guide Ampicillin U6 Promoter Myc-DYKDDDDK Tag Transient
Type:
gRNA + Cas9
Application:
Genome Editing with Engineered Nucleases
Gene:
Phosphatidylinositol-4-Phosphate 5-Kinase, Type I, alpha (PIP5K1A)
Species:
Human
Vector type:
Mammalian Expression Vector
Vector backbone:
pCas-Guide
Resistance Gene:
Ampicillin
Promoter:
U6 Promoter, Enhanced CMV Promoter
Fusion Tag:
Myc-DYKDDDDK Tag
Expression:
Transient
Catalog No. ABIN3230752
$1,640.43
Plus shipping costs $50.00
1 kit
Shipping to: United States
Delivery in 21 to 22 Business Days
Details
Details
Human PIP5K1A cDNA Clone in Mammalian Expression Vector
OriGene sc111072 cDNA PExp Mammalian Expression Vector pCMV6-XL4 Ampicillin Enhanced CMV Promoter unconjugated Transient
Type:
cDNA
Application:
Protein Expression
Gene:
Phosphatidylinositol-4-Phosphate 5-Kinase, Type I, alpha (PIP5K1A)
NCBI Accession:
NM_003557,NP_003548
Species:
Human
Vector type:
Mammalian Expression Vector
Vector backbone:
pCMV6-XL4
Resistance Gene:
Ampicillin
Promoter:
Enhanced CMV Promoter, T7 Promoter
Expression:
Transient
Catalog No. ABIN3379417
$506.88
Plus shipping costs $50.00
10 μg
Shipping to: United States
Delivery in 4 to 9 Business Days
Details
Details
Mouse PIP5K1A cDNA Clone in Mammalian Expression Vector (Myc-DYKDDDDK Tag)
OriGene mc228253 cDNA PExp Mammalian Expression Vector pCMV6-Entry Kanamycin Enhanced CMV Promoter unconjugated Transient
Type:
cDNA
Application:
Protein Expression
Gene:
Phosphatidylinositol-4-Phosphate 5-Kinase, Type I, alpha (PIP5K1A)
NCBI Accession:
NM_001293707,NP_001280636
Species:
Mouse
Vector type:
Mammalian Expression Vector
Vector backbone:
pCMV6-Entry
Resistance Gene:
Kanamycin
Selection Marker:
Neomycin
Promoter:
Enhanced CMV Promoter
Expression:
Transient
Catalog No. ABIN3364532
$555.39
Plus shipping costs $50.00
10 μg
Shipping to: United States
Delivery in 21 to 22 Business Days
Details
Details
Rat PIP5K1A cDNA Clone in Mammalian Expression Vector (Myc-DYKDDDDK Tag)
OriGene rn214780 cDNA PExp Mammalian Expression Vector pCMV6-Entry Kanamycin Enhanced CMV Promoter unconjugated Transient
Type:
cDNA
Application:
Protein Expression
Gene:
Phosphatidylinositol-4-Phosphate 5-Kinase, Type I, alpha (PIP5K1A)
NCBI Accession:
NM_001042621,NP_001036086
Species:
Rat
Vector type:
Mammalian Expression Vector
Vector backbone:
pCMV6-Entry
Resistance Gene:
Kanamycin
Selection Marker:
Neomycin
Promoter:
Enhanced CMV Promoter
Expression:
Transient
Catalog No. ABIN3364533
$554.40
Plus shipping costs $50.00
10 μg
Shipping to: United States
Delivery in 21 to 22 Business Days
Details
Details
Human PIP5K1A ORF Clone in Mammalian Expression Vector (DYKDDDDK Tag)
ORF PExp Mammalian Expression Vector pcDNA3.1+C-(K)-DYK Ampicillin CMV Promoter DYKDDDDK Tag Transient
ISO 9001:2008
Type:
ORF
Application:
Protein Expression
Gene:
Phosphatidylinositol-4-Phosphate 5-Kinase, Type I, alpha (PIP5K1A)
NCBI Accession:
NM_001135638
Gene ID:
8394 (Human, PIP5K1A)
Vector type:
Mammalian Expression Vector
Vector backbone:
pcDNA3.1+C-(K)-DYK
Resistance Gene:
Ampicillin
Selection Marker:
Neomycin
Promoter:
CMV Promoter
Fusion Tag:
DYKDDDDK Tag
Expression:
Transient, Stable
Catalog No. ABIN4936594
$469.00
Plus shipping costs $50.00
10 μg
Shipping to: United States
Delivery in 4 to 7 Business Days
Details
Details
Human PIP5K1A ORF Clone in Mammalian Expression Vector (DYKDDDDK Tag)
ORF PExp Mammalian Expression Vector pcDNA3.1+C-(K)-DYK Ampicillin CMV Promoter DYKDDDDK Tag Transient
ISO 9001:2008
Type:
ORF
Application:
Protein Expression
Gene:
Phosphatidylinositol-4-Phosphate 5-Kinase, Type I, alpha (PIP5K1A)
NCBI Accession:
NM_003557
Gene ID:
8394 (Human, PIP5K1A)
Vector type:
Mammalian Expression Vector
Vector backbone:
pcDNA3.1+C-(K)-DYK
Resistance Gene:
Ampicillin
Selection Marker:
Neomycin
Promoter:
CMV Promoter
Fusion Tag:
DYKDDDDK Tag
Expression:
Transient, Stable
Catalog No. ABIN4936595
$459.00
Plus shipping costs $50.00
10 μg
Shipping to: United States
Delivery in 4 to 7 Business Days
Details
Details
Human PIP5K1A ORF Clone in Mammalian Expression Vector (DYKDDDDK Tag)
ORF PExp Mammalian Expression Vector pcDNA3.1+C-(K)-DYK Ampicillin CMV Promoter DYKDDDDK Tag Transient
ISO 9001:2008
Type:
ORF
Application:
Protein Expression
Gene:
Phosphatidylinositol-4-Phosphate 5-Kinase, Type I, alpha (PIP5K1A)
NCBI Accession:
NM_001135637
Gene ID:
8394 (Human, PIP5K1A)
Vector type:
Mammalian Expression Vector
Vector backbone:
pcDNA3.1+C-(K)-DYK
Resistance Gene:
Ampicillin
Selection Marker:
Neomycin
Promoter:
CMV Promoter
Fusion Tag:
DYKDDDDK Tag
Expression:
Transient, Stable
Catalog No. ABIN4925462
$379.00
Plus shipping costs $50.00
10 μg
Shipping to: United States
Delivery in 6 to 9 Business Days
Details
Details
Human PIP5K1A ORF Clone in Mammalian Expression Vector (DYKDDDDK Tag)
ORF PExp Mammalian Expression Vector pcDNA3.1+C-(K)-DYK Ampicillin CMV Promoter DYKDDDDK Tag Transient
ISO 9001:2008
Type:
ORF
Application:
Protein Expression
Gene:
Phosphatidylinositol-4-Phosphate 5-Kinase, Type I, alpha (PIP5K1A)
NCBI Accession:
NM_001135636
Gene ID:
8394 (Human, PIP5K1A)
Vector type:
Mammalian Expression Vector
Vector backbone:
pcDNA3.1+C-(K)-DYK
Resistance Gene:
Ampicillin
Selection Marker:
Neomycin
Promoter:
CMV Promoter
Fusion Tag:
DYKDDDDK Tag
Expression:
Transient, Stable
Catalog No. ABIN4925463
$429.00
Plus shipping costs $50.00
10 μg
Shipping to: United States
Delivery in 6 to 9 Business Days
Details
Details
  • Type
    • Plasmid
    • Primer
  • Supplier
    • OriGene
    • antibodies-online
    • GenScript
    • ProteoGenix
  • Reactivity
    • Human
    • Mouse
    • Rat
  • Application
    • Protein Expression (PExp)
    • RNA Interference (RNAi)
    • Genome Editing with Engineered Nucleases (GEEN)
    • Cloning (Clon)
  • Conjugate
    • Un-conjugated
    • GFP tag
    • Myc-DYKDDDDK Tag
    • His tag
    • DYKDDDDK Tag
    • HA tag
    • His-GST
    • His-MBP
    • RFP tag
  • Vector Backbone
    • pCMV6-Entry
    • pLenti-U6-sgRNA-PGK-Neo
    • pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
    • pCMV6-AC-GFP
    • pLenti-C-Myc-DDK
    • pLenti-C-mGFP
    • pcDNA3.1+C-(K)-DYK
    • pGFP-C-shLenti
    • pGFP-V-RS
    • pORF
    • pPB-His-GST
    • pPB-His-MBP
    • pPB-N-His
    • pPM-C-HA
    • pPM-C-His
    • pRFP-C-RS
    • pRS
    • pCas-Guide
    • pCMV6-XL4
    • pDONR223
  • Vector
    • Mammalian Expression Vector
    • Lentiviral Vector
    • Bacterial Expression Vector
    • Retroviral Vector
    • Cloning Vector
    • Gateway Cloning Vector
  • Insert
    • ORF
    • cDNA
    • shRNA
    • gRNA + Cas9
    • gRNA
  • Type of Oligonucleotide
    • siRNA Oligo
  • Bacterial Resistance
    • Kanamycin
    • Ampicillin
    • Chloramphenicol
    • Spectinomycin
  • Expression Type
    • Transient
    • Stable
  • Selectable Marker
    • Neomycin
    • Puromycin
  • Promoter
    • CMV Promoter
    • U6 Promoter
    • T7 Promoter
    • Enhanced CMV Promoter
    • PGK Promoter
    • SFFV Promoter
  • Format
    • Lyophilized
    • Liquid
    • Viral Particles

Synonyms and alternative names related to PIP5K1A

  • phosphatidylinositol-4-phosphate 5-kinase type 1 alpha (PIP5K1A)
  • phosphatidylinositol-4-phosphate 5-kinase, type 1, alpha (Pip5k1a)
  • phosphatidylinositol-4-phosphate 5-kinase, type I, alpha L homeolog (pip5k1a.L)
  • phosphatidylinositol-4-phosphate 5-kinase, type I, alpha (pip5k1a)
  • phosphatidylinositol-4-phosphate 5-kinase, type 1 alpha (Pip5k1a)
  • phosphatidylinositol-4-phosphate 5-kinase, type I, alpha, a (pip5k1aa)
  • phosphatidylinositol-4-phosphate 5-kinase type 1 alpha (Pip5k1a)
  • phosphatidylinositol-4-phosphate 5-kinase, type I, alpha, b (pip5k1ab)
  • im:7140933
  • PIP5K1A
  • pip5k1a
  • Pip5k1b
  • pip5k1b
  • pip5k1c
  • Pipk5a
  • Pipk5b
  • zgc:110576
  • zgc:158838

Gene-IDs for different species

Protein level used designations for PIP5K1A

  • 68 kDa type I phosphatidylinositol 4-phosphate 5-kinase alpha
  • 68 kDa type I phosphatidylinositol-4-phosphate 5-kinase alpha
  • PIP5K1-alpha
  • PIP5KIalpha
  • phosphatidylinositol 4-phosphate 5-kinase type I alpha
  • phosphatidylinositol 4-phosphate 5-kinase type-1 alpha
  • phosphatidylinositol-4-phosphate 5-kinase type-1 alpha
  • ptdIns(4)P-5-kinase 1 alpha
  • phosphatidylinositol-4-phosphate 5-kinase, type 1 beta
  • phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
  • phosphatidylinositol-4-phosphate 5-kinase, type I, beta
  • 68 kDa type I phosphatidylinositol 4-phosphate 5-kinase
  • 68 kDa type I phosphatidylinositol-4-phosphate 5-kinase
  • PI4P5K-I[a]
  • PI4P5KIbeta
  • phosphatidylinositol 4-phosphate 5-kinase type I beta
  • phosphatidylinositol-4-phosphate 5-kinase type I alpha
  • phosphatidylinositol-4-phosphate 5-kinase type I beta
  • phosphatidylinositol-4-phosphate 5-kinase type-1 gamma
Other products related to PIP5K1A such as antibodies, ELISA kits and high-purity proteins are available on our partner website antibodies-online.com
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