PIP5K1A (Phosphatidylinositol-4-Phosphate 5-Kinase, Type I, alpha, PIP5K1A)
Short Description: Catalyzes the phosphorylation of phosphatidylinositol 4- phosphate (PtdIns4P) to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). PtdIns(4,5)P2 is involved in a variety of cellular processes and is the substrate to form phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3), another second messenger. The majority of PtdIns(4,5)P2 is thought to occur via type I phosphatidylinositol 4-phosphate 5-kinases given the abundance of PtdIns4P. Participates in a variety of cellular processes such as actin cytoskeleton organization, cell adhesion, migration and phagocytosis. Required for membrane ruffling formation, actin organization and focal adhesion formation during directional cell migration by controlling integrin-induced translocation of RAC1 to the plasma membrane. Together with PIP5K1C is required for phagocytosis, but they regulate different types of actin remodeling at sequential steps. Promotes particle ingestion by activating WAS that induces Arp2/3 dependent actin polymerization at the nascent phagocytic cup. Together with PIP5K1B is required after stimulation of G-protein coupled receptors for stable platelet adhesion. Plays a role during calcium-induced keratinocyte differentiation. Recruited to the plasma membrane by the E-cadherin/beta-catenin complex where it provides the substrate PtdIns(4,5)P2 for the production of PtdIns(3,4,5)P3, diacylglycerol and inositol 1,4,5-trisphosphate that mobilize internal calcium and drive keratinocyte differentiation. Together with PIP5K1C have a role during embryogenesis. Functions also in the nucleus where acts as an activator of TUT1 adenylyltransferase activity in nuclear speckles, thereby regulating mRNA polyadenylation of a select set of mRNAs.
More information related to gene PIP5K1A.
More information related to gene PIP5K1A.
Products related to PIP5K1A Gene:
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73 results
OriGene tr310416
shRNA
RNAi
Retroviral Vector
pRS
Ampicillin
U6 Promoter
unconjugated
Transient
1
- Type:
- shRNA
- Application:
- RNA Interference
- Gene:
- Phosphatidylinositol-4-Phosphate 5-Kinase, Type I, alpha (PIP5K1A)
- Species:
- Human
- Vector type:
- Retroviral Vector
- Vector backbone:
- pRS
- Resistance Gene:
- Ampicillin
- Selection Marker:
- Puromycin
- Promoter:
- U6 Promoter
- Expression:
- Transient, Stable
Catalog No. ABIN3652377
$874.17
Plus shipping costs $50.00
1 kit
Shipping to:
United States
Delivery in 16 to 17 Business Days
OriGene tf703682
shRNA
RNAi
Retroviral Vector
pRFP-C-RS
Chloramphenicol
U6 Promoter
RFP tag
Transient
1
- Type:
- shRNA
- Application:
- RNA Interference
- Gene:
- Phosphatidylinositol-4-Phosphate 5-Kinase, Type I, alpha (PIP5K1A)
- Species:
- Rat
- Vector type:
- Retroviral Vector
- Vector backbone:
- pRFP-C-RS
- Resistance Gene:
- Chloramphenicol
- Selection Marker:
- Puromycin
- Promoter:
- U6 Promoter
- Fusion Tag:
- RFP tag
- Expression:
- Transient, Stable
Catalog No. ABIN3608226
$707.85
Plus shipping costs $50.00
1 kit
Shipping to:
United States
Delivery in 16 to 17 Business Days
OriGene tr516250
shRNA
RNAi
Retroviral Vector
pRS
Ampicillin
U6 Promoter
unconjugated
Transient
1
- Type:
- shRNA
- Application:
- RNA Interference
- Gene:
- Phosphatidylinositol-4-Phosphate 5-Kinase, Type I, alpha (PIP5K1A)
- Species:
- Mouse
- Vector type:
- Retroviral Vector
- Vector backbone:
- pRS
- Resistance Gene:
- Ampicillin
- Selection Marker:
- Puromycin
- Promoter:
- U6 Promoter
- Expression:
- Transient, Stable
Catalog No. ABIN3549247
$874.17
Plus shipping costs $50.00
1 kit
Shipping to:
United States
Delivery in 16 to 17 Business Days
OriGene tl516250
shRNA
RNAi
Lentiviral Vector
pGFP-C-shLenti
Chloramphenicol
U6 Promoter
GFP tag
Transient
1
- Type:
- shRNA
- Application:
- RNA Interference
- Gene:
- Phosphatidylinositol-4-Phosphate 5-Kinase, Type I, alpha (PIP5K1A)
- Species:
- Mouse
- Vector type:
- Lentiviral Vector
- Vector backbone:
- pGFP-C-shLenti
- Resistance Gene:
- Chloramphenicol
- Selection Marker:
- Puromycin
- Promoter:
- U6 Promoter
- Fusion Tag:
- GFP tag
- Expression:
- Transient, Stable
Catalog No. ABIN3528839
$1,002.87
Plus shipping costs $50.00
1 kit
Shipping to:
United States
Delivery in 16 to 17 Business Days
OriGene tr703682
shRNA
RNAi
Retroviral Vector
pRS
Ampicillin
U6 Promoter
unconjugated
Transient
1
- Type:
- shRNA
- Application:
- RNA Interference
- Gene:
- Phosphatidylinositol-4-Phosphate 5-Kinase, Type I, alpha (PIP5K1A)
- Species:
- Rat
- Vector type:
- Retroviral Vector
- Vector backbone:
- pRS
- Resistance Gene:
- Ampicillin
- Selection Marker:
- Puromycin
- Promoter:
- U6 Promoter
- Expression:
- Transient, Stable
Catalog No. ABIN3443463
$874.17
Plus shipping costs $50.00
1 kit
Shipping to:
United States
Delivery in 16 to 17 Business Days
OriGene tg703682
shRNA
RNAi
Retroviral Vector
pGFP-V-RS
Kanamycin
U6 Promoter
GFP tag
Transient
1
- Type:
- shRNA
- Application:
- RNA Interference
- Gene:
- Phosphatidylinositol-4-Phosphate 5-Kinase, Type I, alpha (PIP5K1A)
- Species:
- Rat
- Vector type:
- Retroviral Vector
- Vector backbone:
- pGFP-V-RS
- Resistance Gene:
- Kanamycin
- Selection Marker:
- Puromycin
- Promoter:
- U6 Promoter
- Fusion Tag:
- GFP tag
- Expression:
- Transient, Stable
Catalog No. ABIN3497908
$707.85
Plus shipping costs $50.00
1 kit
Shipping to:
United States
Delivery in 16 to 17 Business Days
OriGene sc326023
cDNA
PExp
Mammalian Expression Vector
pCMV6-Entry
Kanamycin
Enhanced CMV Promoter
unconjugated
Transient
1
- Type:
- cDNA
- Application:
- Protein Expression
- Gene:
- Phosphatidylinositol-4-Phosphate 5-Kinase, Type I, alpha (PIP5K1A)
- NCBI Accession:
- NM_001135636,NP_001129108
- Species:
- Human
- Vector type:
- Mammalian Expression Vector
- Vector backbone:
- pCMV6-Entry
- Resistance Gene:
- Kanamycin
- Selection Marker:
- Neomycin
- Promoter:
- Enhanced CMV Promoter
- Expression:
- Transient
Catalog No. ABIN3303901
$530.64
Plus shipping costs $50.00
10 μg
Shipping to:
United States
Delivery in 21 to 22 Business Days
OriGene sc326069
cDNA
PExp
Mammalian Expression Vector
pCMV6-Entry
Kanamycin
Enhanced CMV Promoter
unconjugated
Transient
1
- Type:
- cDNA
- Application:
- Protein Expression
- Gene:
- Phosphatidylinositol-4-Phosphate 5-Kinase, Type I, alpha (PIP5K1A)
- NCBI Accession:
- NM_001135638,NP_001129110
- Species:
- Human
- Vector type:
- Mammalian Expression Vector
- Vector backbone:
- pCMV6-Entry
- Resistance Gene:
- Kanamycin
- Selection Marker:
- Neomycin
- Promoter:
- Enhanced CMV Promoter
- Expression:
- Transient
Catalog No. ABIN3303902
$570.24
Plus shipping costs $50.00
10 μg
Shipping to:
United States
Delivery in 21 to 22 Business Days
OriGene sr411933
RNAi
PIP5K1A
Species: Mouse
HPLC purified
- Application:
- RNA Interference
- Gene:
- Phosphatidylinositol-4-Phosphate 5-Kinase, Type I, alpha
- Species:
- Mouse
- Purification:
- HPLC purified
Catalog No. ABIN3268026
$512.82
Plus shipping costs $50.00
1 kit
Shipping to:
United States
Delivery in 16 to 17 Business Days
OriGene sr514490
RNAi
PIP5K1A
Species: Rat
HPLC purified
- Application:
- RNA Interference
- Gene:
- Phosphatidylinositol-4-Phosphate 5-Kinase, Type I, alpha
- Species:
- Rat
- Purification:
- HPLC purified
Catalog No. ABIN3315943
$512.82
Plus shipping costs $50.00
1 kit
Shipping to:
United States
Delivery in 16 to 17 Business Days
Synonyms and alternative names related to PIP5K1A
- phosphatidylinositol-4-phosphate 5-kinase type 1 alpha (PIP5K1A)
- phosphatidylinositol-4-phosphate 5-kinase, type 1, alpha (Pip5k1a)
- phosphatidylinositol-4-phosphate 5-kinase, type I, alpha L homeolog (pip5k1a.L)
- phosphatidylinositol-4-phosphate 5-kinase, type I, alpha (pip5k1a)
- phosphatidylinositol-4-phosphate 5-kinase, type 1 alpha (Pip5k1a)
- phosphatidylinositol-4-phosphate 5-kinase, type I, alpha, a (pip5k1aa)
- phosphatidylinositol-4-phosphate 5-kinase type 1 alpha (Pip5k1a)
- phosphatidylinositol-4-phosphate 5-kinase, type I, alpha, b (pip5k1ab)
- im:7140933
- PIP5K1A
- pip5k1a
- Pip5k1b
- pip5k1b
- pip5k1c
- Pipk5a
- Pipk5b
- zgc:110576
- zgc:158838
Gene-IDs for different species
Protein level used designations for PIP5K1A
- 68 kDa type I phosphatidylinositol 4-phosphate 5-kinase alpha
- 68 kDa type I phosphatidylinositol-4-phosphate 5-kinase alpha
- PIP5K1-alpha
- PIP5KIalpha
- phosphatidylinositol 4-phosphate 5-kinase type I alpha
- phosphatidylinositol 4-phosphate 5-kinase type-1 alpha
- phosphatidylinositol-4-phosphate 5-kinase type-1 alpha
- ptdIns(4)P-5-kinase 1 alpha
- phosphatidylinositol-4-phosphate 5-kinase, type 1 beta
- phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
- phosphatidylinositol-4-phosphate 5-kinase, type I, beta
- 68 kDa type I phosphatidylinositol 4-phosphate 5-kinase
- 68 kDa type I phosphatidylinositol-4-phosphate 5-kinase
- PI4P5K-I[a]
- PI4P5KIbeta
- phosphatidylinositol 4-phosphate 5-kinase type I beta
- phosphatidylinositol-4-phosphate 5-kinase type I alpha
- phosphatidylinositol-4-phosphate 5-kinase type I beta
- phosphatidylinositol-4-phosphate 5-kinase type-1 gamma
Proteomics products related to PIP5K1A Gene
Other products related to PIP5K1A such as antibodies, ELISA kits and high-purity proteins are available on our partner website antibodies-online.com
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