APH1A (Anterior Pharynx Defective 1 Homolog A (C. Elegans), APH1A)
Short Description: This gene encodes a component of the gamma secretase complex that cleaves integral membrane proteins such as Notch receptors and beta-amyloid precursor protein. The gamma secretase complex contains this gene product, or the paralogous anterior pharynx defective 1 homolog B (APH1B), along with the presenilin, nicastrin, and presenilin enhancer-2 proteins. The precise function of this seven-transmembrane-domain protein is unknown though it is suspected of facilitating the association of nicastrin and presenilin in the gamma secretase complex as well as interacting with substrates of the gamma secretase complex prior to their proteolytic processing. Polymorphisms in a promoter region of this gene have been associated with an increased risk for developing sporadic Alzheimer's disease. Alternative splicing results in multiple protein-coding and non-protein-coding transcript variants. [provided by RefSeq, Aug 2011].
More information related to gene APH1A.
More information related to gene APH1A.
Products related to APH1A Gene:
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91 results
cDNA
PExp
Mammalian Expression Vector
pPM-C-His
Kanamycin
CMV Promoter
His tag
Stable
- Type:
- cDNA
- Application:
- Protein Expression
- Gene:
- Anterior Pharynx Defective 1 Homolog A (C. Elegans) (APH1A)
- NCBI Accession:
- NM_001014255
- Species:
- Rat
- Vector type:
- Mammalian Expression Vector
- Vector backbone:
- pPM-C-His
- Resistance Gene:
- Kanamycin
- Selection Marker:
- Neomycin
- Promoter:
- CMV Promoter
- Fusion Tag:
- His tag
- Expression:
- Stable, Transient
Catalog No. ABIN4497135
$1,441.35
Plus shipping costs $50.00
500 ng
Shipping to:
United States
Delivery in 21 to 31 Business Days
cDNA
Clon
Bacterial Expression Vector
pPB-N-His
Kanamycin
T7 Promoter
His tag
Transient
- Type:
- cDNA
- Application:
- Cloning
- Gene:
- Anterior Pharynx Defective 1 Homolog A (C. Elegans) (APH1A)
- NCBI Accession:
- NM_001014255
- Species:
- Rat
- Vector type:
- Bacterial Expression Vector
- Vector backbone:
- pPB-N-His
- Resistance Gene:
- Kanamycin
- Promoter:
- T7 Promoter
- Fusion Tag:
- His tag
- Expression:
- Transient
Catalog No. ABIN4676824
$1,441.35
Plus shipping costs $50.00
500 ng
Shipping to:
United States
Delivery in 21 to 31 Business Days
gRNA
PExp, GEEN
Lentiviral Vector
pLenti-U6-sgRNA-PGK-Neo
Ampicillin
U6 Promoter
unconjugated
Stable
- Type:
- gRNA
- Application:
- Protein Expression, Genome Editing with Engineered Nucleases
- Gene:
- Anterior Pharynx Defective 1 Homolog A (C. Elegans) (APH1A)
- NCBI Accession:
- NM_001077628
- Species:
- Human
- Vector type:
- Lentiviral Vector
- Vector backbone:
- pLenti-U6-sgRNA-PGK-Neo
- Resistance Gene:
- Ampicillin
- Selection Marker:
- Neomycin
- Promoter:
- U6 Promoter, PGK Promoter
- Expression:
- Stable, Transient
Catalog No. ABIN5083855
$1,511.06
Plus shipping costs $50.00, if applicable $20.00 dry ice
3 x 300 μL
Shipping to:
United States
Delivery in 31 to 41 Business Days
gRNA
PExp, GEEN
Lentiviral Vector
pLenti-U6-sgRNA-PGK-Neo
Ampicillin
U6 Promoter
unconjugated
Stable
- Type:
- gRNA
- Application:
- Protein Expression, Genome Editing with Engineered Nucleases
- Gene:
- Anterior Pharynx Defective 1 Homolog A (C. Elegans) (APH1A)
- NCBI Accession:
- NM_001014255
- Species:
- Rat
- Vector type:
- Lentiviral Vector
- Vector backbone:
- pLenti-U6-sgRNA-PGK-Neo
- Resistance Gene:
- Ampicillin
- Selection Marker:
- Neomycin
- Promoter:
- U6 Promoter, PGK Promoter
- Expression:
- Stable, Transient
Catalog No. ABIN5083859
$1,511.06
Plus shipping costs $50.00, if applicable $20.00 dry ice
3 x 300 μL
Shipping to:
United States
Delivery in 31 to 41 Business Days
gRNA
PExp, GEEN
Lentiviral Vector
pLenti-U6-sgRNA-PGK-Neo
Ampicillin
U6 Promoter
unconjugated
Stable
- Type:
- gRNA
- Application:
- Protein Expression, Genome Editing with Engineered Nucleases
- Gene:
- Anterior Pharynx Defective 1 Homolog A (C. Elegans) (APH1A)
- NCBI Accession:
- NM_146104
- Species:
- Mouse
- Vector type:
- Lentiviral Vector
- Vector backbone:
- pLenti-U6-sgRNA-PGK-Neo
- Resistance Gene:
- Ampicillin
- Selection Marker:
- Neomycin
- Promoter:
- U6 Promoter, PGK Promoter
- Expression:
- Stable, Transient
Catalog No. ABIN5083857
$1,511.06
Plus shipping costs $50.00, if applicable $20.00 dry ice
3 x 300 μL
Shipping to:
United States
Delivery in 31 to 41 Business Days
gRNA + Cas9
PExp, GEEN
Lentiviral Vector
pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
Ampicillin
U6 Promoter
unconjugated
Stable
- Type:
- gRNA + Cas9
- Application:
- Protein Expression, Genome Editing with Engineered Nucleases
- Gene:
- Anterior Pharynx Defective 1 Homolog A (C. Elegans) (APH1A)
- NCBI Accession:
- NM_001014255
- Species:
- Rat
- Vector type:
- Lentiviral Vector
- Vector backbone:
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- Resistance Gene:
- Ampicillin
- Selection Marker:
- Puromycin
- Promoter:
- U6 Promoter, SFFV Promoter
- Expression:
- Stable, Transient
Catalog No. ABIN5198987
$1,968.75
Plus shipping costs $50.00, if applicable $20.00 dry ice
3 x 300 μL
Shipping to:
United States
Delivery in 31 to 41 Business Days
gRNA + Cas9
PExp, GEEN
Lentiviral Vector
pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
Ampicillin
U6 Promoter
unconjugated
Stable
- Type:
- gRNA + Cas9
- Application:
- Protein Expression, Genome Editing with Engineered Nucleases
- Gene:
- Anterior Pharynx Defective 1 Homolog A (C. Elegans) (APH1A)
- NCBI Accession:
- NM_001077628
- Species:
- Human
- Vector type:
- Lentiviral Vector
- Vector backbone:
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- Resistance Gene:
- Ampicillin
- Selection Marker:
- Puromycin
- Promoter:
- U6 Promoter, SFFV Promoter
- Expression:
- Stable, Transient
Catalog No. ABIN5198983
$1,968.75
Plus shipping costs $50.00, if applicable $20.00 dry ice
3 x 300 μL
Shipping to:
United States
Delivery in 31 to 41 Business Days
gRNA + Cas9
PExp, GEEN
Lentiviral Vector
pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
Ampicillin
U6 Promoter
unconjugated
Stable
- Type:
- gRNA + Cas9
- Application:
- Protein Expression, Genome Editing with Engineered Nucleases
- Gene:
- Anterior Pharynx Defective 1 Homolog A (C. Elegans) (APH1A)
- NCBI Accession:
- NM_146104
- Species:
- Mouse
- Vector type:
- Lentiviral Vector
- Vector backbone:
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- Resistance Gene:
- Ampicillin
- Selection Marker:
- Puromycin
- Promoter:
- U6 Promoter, SFFV Promoter
- Expression:
- Stable, Transient
Catalog No. ABIN5198985
$1,968.75
Plus shipping costs $50.00, if applicable $20.00 dry ice
3 x 300 μL
Shipping to:
United States
Delivery in 31 to 41 Business Days
ORF
PExp
Mammalian Expression Vector
pcDNA3.1+C-(K)-DYK
Ampicillin
CMV Promoter
DYKDDDDK Tag
Transient
- Type:
- ORF
- Application:
- Protein Expression
- Gene:
- Anterior Pharynx Defective 1 Homolog A (C. Elegans) (APH1A)
- NCBI Accession:
- NM_001243771
- Gene ID:
- 51107 (Human, APH1A)
- Vector type:
- Mammalian Expression Vector
- Vector backbone:
- pcDNA3.1+C-(K)-DYK
- Resistance Gene:
- Ampicillin
- Selection Marker:
- Neomycin
- Promoter:
- CMV Promoter
- Fusion Tag:
- DYKDDDDK Tag
- Expression:
- Transient, Stable
Catalog No. ABIN4933191
ORF
PExp
Mammalian Expression Vector
pcDNA3.1+C-(K)-DYK
Ampicillin
CMV Promoter
DYKDDDDK Tag
Transient
- Type:
- ORF
- Application:
- Protein Expression
- Gene:
- Anterior Pharynx Defective 1 Homolog A (C. Elegans) (APH1A)
- NCBI Accession:
- NM_001243772
- Gene ID:
- 51107 (Human, APH1A)
- Vector type:
- Mammalian Expression Vector
- Vector backbone:
- pcDNA3.1+C-(K)-DYK
- Resistance Gene:
- Ampicillin
- Selection Marker:
- Neomycin
- Promoter:
- CMV Promoter
- Fusion Tag:
- DYKDDDDK Tag
- Expression:
- Transient, Stable
Catalog No. ABIN4933192
Synonyms and alternative names related to APH1A
- aph-1 homolog A, gamma-secretase subunit (APH1A)
- aph-1 homolog A, gamma secretase subunit L homeolog (aph1a.L)
- aph-1 homolog A, gamma secretase subunit (Aph1a)
- anterior pharynx defective 1 homolog A (C. elegans) (APH1A)
- aph1 homolog A, gamma secretase subunit (Aph1a)
- acylamino-acid-releasing enzyme-like (LOC100219182)
- 6530402N02Rik
- APH-1
- APH-1A
- APH-1a
- CGI-78
- RGD1311546
Gene-IDs for different species
Protein level used designations for APH1A
- anterior pharynx defective 1 homolog A
- aph-1alpha
- gamma-secretase subunit APH-1A
- presenilin-stabilization factor
- anterior pharynx defective 1a homolog
- N-acylaminoacyl-peptide hydrolase
Proteomics products related to APH1A Gene
Other products related to APH1A such as antibodies, ELISA kits and high-purity proteins are available on our partner website antibodies-online.com
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