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DKC1 (Dyskeratosis Congenita 1, Dyskerin, DKC1)

Short Description: This gene is a member of the H/ACA snoRNPs (small nucleolar ribonucleoproteins) gene family. snoRNPs are involved in various aspects of rRNA processing and modification and have been classified into two families: C/D and H/ACA. The H/ACA snoRNPs also include the NOLA1, 2 and 3 proteins. The protein encoded by this gene and the three NOLA proteins localize to the dense fibrillar components of nucleoli and to coiled (Cajal) bodies in the nucleus. Both 18S rRNA production and rRNA pseudouridylation are impaired if any one of the four proteins is depleted. These four H/ACA snoRNP proteins are also components of the telomerase complex. The protein encoded by this gene is related to the Saccharomyces cerevisiae Cbf5p and Drosophila melanogaster Nop60B proteins. The gene lies in a tail-to-tail orientation with the palmitoylated erythrocyte membrane protein gene and is transcribed in a telomere to centromere direction. Both nucleotide substitutions and single trinucleotide repeat polymorphisms have been found in this gene. Mutations in this gene cause X-linked dyskeratosis congenita, a disease resulting in reticulate skin pigmentation, mucosal leukoplakia, nail dystrophy, and progressive bone marrow failure in most cases. Mutations in this gene also cause Hoyeraal-Hreidarsson syndrome, which is a more severe form of dyskeratosis congenita. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2013].
More information related to gene DKC1.

Products related to DKC1 Gene:

76 results :

Human DKC1 ORF Clone in Cloning Vector
ORF Clon Cloning Vector pORF Spectinomycin unconjugated Transient
Type:
ORF
Application:
Cloning
Gene:
Dyskeratosis Congenita 1, Dyskerin (DKC1)
Species:
Human
Vector type:
Cloning Vector
Vector backbone:
pORF
Resistance Gene:
Spectinomycin
Expression:
Transient
Catalog No. ABIN5722921
Datasheet
Catalog No. ABIN5722921
Type:
ORF
Application:
Cloning
Gene:
Dyskeratosis Congenita 1, Dyskerin (DKC1)
Species:
Human
Synonyms:
DKC1, MIR664B, dkc1, dkc1.L, Dkc1, NAP57
Insert length:
1545 bp
Vector type:
Cloning Vector
Vector backbone:
pORF
Resistance Gene:
Spectinomycin
Expression:
Transient
Sequencing Primer:
  • M13 FP: 5'-CCCAGTCACGACGTTGTAAAACG-3'
    M13 RP: 5'-CAGGAAACAGCTATGAC-3'
Format:
Liquid
Buffer:
10  mM Tris-HCI, 1  mM EDTA,  pH 8.0
Storage:
-20 °C
Human DKC1 ORF Clone in Cloning Vector
ORF Clon Cloning Vector pORF Spectinomycin unconjugated Transient
Type:
ORF
Application:
Cloning
Gene:
Dyskeratosis Congenita 1, Dyskerin (DKC1)
Species:
Human
Vector type:
Cloning Vector
Vector backbone:
pORF
Resistance Gene:
Spectinomycin
Expression:
Transient
Catalog No. ABIN5722922
Datasheet
Catalog No. ABIN5722922
Type:
ORF
Application:
Cloning
Gene:
Dyskeratosis Congenita 1, Dyskerin (DKC1)
Species:
Human
Synonyms:
DKC1, MIR664B, dkc1, dkc1.L, Dkc1, NAP57
Insert length:
1545 bp
Vector type:
Cloning Vector
Vector backbone:
pORF
Resistance Gene:
Spectinomycin
Expression:
Transient
Sequencing Primer:
  • M13 FP: 5'-CCCAGTCACGACGTTGTAAAACG-3'
    M13 RP: 5'-CAGGAAACAGCTATGAC-3'
Format:
Liquid
Buffer:
10  mM Tris-HCI, 1  mM EDTA,  pH 8.0
Storage:
-20 °C
Human DKC1 cDNA Clone in Mammalian Expression Vector (HA tag)
cDNA PExp Mammalian Expression Vector pPM-C-HA Kanamycin CMV Promoter HA tag Stable
Type:
cDNA
Application:
Protein Expression
Gene:
Dyskeratosis Congenita 1, Dyskerin (DKC1)
Species:
Human
Vector type:
Mammalian Expression Vector
Vector backbone:
pPM-C-HA
Resistance Gene:
Kanamycin
Selection Marker:
Neomycin
Promoter:
CMV Promoter
Fusion Tag:
HA tag
Expression:
Stable, Transient
Catalog No. ABIN4474744
Datasheet
Catalog No. ABIN4474744
Type:
cDNA
Application:
Protein Expression
Gene:
Dyskeratosis Congenita 1, Dyskerin (DKC1)
Species:
Human
Synonyms:
DKC1, MIR664B, dkc1, dkc1.L, Dkc1, NAP57
Insert length:
1545 bp
Vector type:
Mammalian Expression Vector
Vector backbone:
pPM-C-HA
Resistance Gene:
Kanamycin
Selection Marker:
Neomycin
Promoter:
CMV Promoter
Fusion Tag:
HA tag
Expression:
Stable, Transient
Sequencing Primer:
  • CMV sequencing primer: 5` CGC AAA TGG GCG GTA GGC GTG 3`
Format:
Liquid
Buffer:
10 mM Tris-HCI, 1 mM EDTA, pH 8.0
Storage:
-20 °C
Human DKC1 cDNA Clone in Mammalian Expression Vector (HA tag)
cDNA PExp Mammalian Expression Vector pPM-C-HA Kanamycin CMV Promoter HA tag Stable
Type:
cDNA
Application:
Protein Expression
Gene:
Dyskeratosis Congenita 1, Dyskerin (DKC1)
Species:
Human
Vector type:
Mammalian Expression Vector
Vector backbone:
pPM-C-HA
Resistance Gene:
Kanamycin
Selection Marker:
Neomycin
Promoter:
CMV Promoter
Fusion Tag:
HA tag
Expression:
Stable, Transient
Catalog No. ABIN4474745
Datasheet
Catalog No. ABIN4474745
Type:
cDNA
Application:
Protein Expression
Gene:
Dyskeratosis Congenita 1, Dyskerin (DKC1)
Species:
Human
Synonyms:
DKC1, MIR664B, dkc1, dkc1.L, Dkc1, NAP57
Insert length:
1545 bp
Vector type:
Mammalian Expression Vector
Vector backbone:
pPM-C-HA
Resistance Gene:
Kanamycin
Selection Marker:
Neomycin
Promoter:
CMV Promoter
Fusion Tag:
HA tag
Expression:
Stable, Transient
Sequencing Primer:
  • CMV sequencing primer: 5` CGC AAA TGG GCG GTA GGC GTG 3`
Format:
Liquid
Buffer:
10 mM Tris-HCI, 1 mM EDTA, pH 8.0
Storage:
-20 °C
Rat DKC1 CRISPR gRNA in Lenti Particles
gRNA PExp, GEEN Lentiviral Vector pLenti-U6-sgRNA-PGK-Neo Ampicillin U6 Promoter unconjugated Stable
Type:
gRNA
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
Dyskeratosis Congenita 1, Dyskerin (DKC1)
NCBI Accession:
NM_133419
Species:
Rat
Vector type:
Lentiviral Vector
Vector backbone:
pLenti-U6-sgRNA-PGK-Neo
Resistance Gene:
Ampicillin
Selection Marker:
Neomycin
Promoter:
U6 Promoter, PGK Promoter
Expression:
Stable, Transient
Catalog No. ABIN5087184
Datasheet
Catalog No. ABIN5087184
Type:
gRNA
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
Dyskeratosis Congenita 1, Dyskerin (DKC1)
NCBI Accession:
NM_133419
Species:
Rat
Synonyms:
DKC1, MIR664B, dkc1, dkc1.L, Dkc1, NAP57
Vector type:
Lentiviral Vector
Vector backbone:
pLenti-U6-sgRNA-PGK-Neo
Resistance Gene:
Ampicillin
Selection Marker:
Neomycin
Promoter:
U6 Promoter, PGK Promoter
Expression:
Stable, Transient
Components:
Lentiviral particles with an individual gRNA (300 μL) for a specific sequence of Dkc1
Format:
Viral Particles
Storage:
-80 °C
Mouse DKC1 CRISPR gRNA in Lenti Particles
gRNA PExp, GEEN Lentiviral Vector pLenti-U6-sgRNA-PGK-Neo Ampicillin U6 Promoter unconjugated Stable
Type:
gRNA
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
Dyskeratosis Congenita 1, Dyskerin (DKC1)
NCBI Accession:
NM_001030307
Species:
Mouse
Vector type:
Lentiviral Vector
Vector backbone:
pLenti-U6-sgRNA-PGK-Neo
Resistance Gene:
Ampicillin
Selection Marker:
Neomycin
Promoter:
U6 Promoter, PGK Promoter
Expression:
Stable, Transient
Catalog No. ABIN5087182
Datasheet
Catalog No. ABIN5087182
Type:
gRNA
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
Dyskeratosis Congenita 1, Dyskerin (DKC1)
NCBI Accession:
NM_001030307
Species:
Mouse
Synonyms:
DKC1, MIR664B, dkc1, dkc1.L, Dkc1, NAP57
Vector type:
Lentiviral Vector
Vector backbone:
pLenti-U6-sgRNA-PGK-Neo
Resistance Gene:
Ampicillin
Selection Marker:
Neomycin
Promoter:
U6 Promoter, PGK Promoter
Expression:
Stable, Transient
Components:
Lentiviral particles with an individual gRNA (300 μL) for a specific sequence of Dkc1
Format:
Viral Particles
Storage:
-80 °C
Human DKC1 CRISPR gRNA in Lenti Particles
gRNA PExp, GEEN Lentiviral Vector pLenti-U6-sgRNA-PGK-Neo Ampicillin U6 Promoter unconjugated Stable
Type:
gRNA
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
Dyskeratosis Congenita 1, Dyskerin (DKC1)
NCBI Accession:
NM_001363
Species:
Human
Vector type:
Lentiviral Vector
Vector backbone:
pLenti-U6-sgRNA-PGK-Neo
Resistance Gene:
Ampicillin
Selection Marker:
Neomycin
Promoter:
U6 Promoter, PGK Promoter
Expression:
Stable, Transient
Catalog No. ABIN5087180
Datasheet
Catalog No. ABIN5087180
Type:
gRNA
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
Dyskeratosis Congenita 1, Dyskerin (DKC1)
NCBI Accession:
NM_001363
Species:
Human
Synonyms:
DKC1, MIR664B, dkc1, dkc1.L, Dkc1, NAP57
Vector type:
Lentiviral Vector
Vector backbone:
pLenti-U6-sgRNA-PGK-Neo
Resistance Gene:
Ampicillin
Selection Marker:
Neomycin
Promoter:
U6 Promoter, PGK Promoter
Expression:
Stable, Transient
Components:
Lentiviral particles with an individual gRNA (300 μL) for a specific sequence of DKC1
Format:
Viral Particles
Storage:
-80 °C
Human DKC1 cDNA Clone in Bacterial Expression Vector (His tag)
cDNA Clon Bacterial Expression Vector pPB-N-His Kanamycin T7 Promoter His tag Transient
Type:
cDNA
Application:
Cloning
Gene:
Dyskeratosis Congenita 1, Dyskerin (DKC1)
Species:
Human
Vector type:
Bacterial Expression Vector
Vector backbone:
pPB-N-His
Resistance Gene:
Kanamycin
Promoter:
T7 Promoter
Fusion Tag:
His tag
Expression:
Transient
Catalog No. ABIN4761120
Datasheet
Catalog No. ABIN4761120
Type:
cDNA
Application:
Cloning
Gene:
Dyskeratosis Congenita 1, Dyskerin (DKC1)
Species:
Human
Synonyms:
DKC1, MIR664B, dkc1, dkc1.L, Dkc1, NAP57
Insert length:
1545 bp
Vector type:
Bacterial Expression Vector
Vector backbone:
pPB-N-His
Resistance Gene:
Kanamycin
Promoter:
T7 Promoter
Fusion Tag:
His tag
Expression:
Transient
Sequencing Primer:
  • T7 promoter primer: 5'-TAATACGACTCACTATAGGG-3'
  • T7 terminator primer: 5'-GCTAGTTATTGCTCAGCGG-3'
Format:
Liquid
Buffer:
10 mM Tris-HCI, 1 mM EDTA, pH 8.0
Storage:
-20 °C
Human DKC1 cDNA Clone in Bacterial Expression Vector (His tag)
cDNA Clon Bacterial Expression Vector pPB-N-His Kanamycin T7 Promoter His tag Transient
Type:
cDNA
Application:
Cloning
Gene:
Dyskeratosis Congenita 1, Dyskerin (DKC1)
Species:
Human
Vector type:
Bacterial Expression Vector
Vector backbone:
pPB-N-His
Resistance Gene:
Kanamycin
Promoter:
T7 Promoter
Fusion Tag:
His tag
Expression:
Transient
Catalog No. ABIN4761119
Datasheet
Catalog No. ABIN4761119
Type:
cDNA
Application:
Cloning
Gene:
Dyskeratosis Congenita 1, Dyskerin (DKC1)
Species:
Human
Synonyms:
DKC1, MIR664B, dkc1, dkc1.L, Dkc1, NAP57
Insert length:
1545 bp
Vector type:
Bacterial Expression Vector
Vector backbone:
pPB-N-His
Resistance Gene:
Kanamycin
Promoter:
T7 Promoter
Fusion Tag:
His tag
Expression:
Transient
Sequencing Primer:
  • T7 promoter primer: 5'-TAATACGACTCACTATAGGG-3'
  • T7 terminator primer: 5'-GCTAGTTATTGCTCAGCGG-3'
Format:
Liquid
Buffer:
10 mM Tris-HCI, 1 mM EDTA, pH 8.0
Storage:
-20 °C
Human DKC1 cDNA Clone in Bacterial Expression Vector (His-GST)
cDNA Clon Bacterial Expression Vector pPB-His-GST Kanamycin T7 Promoter His-GST Transient
Type:
cDNA
Application:
Cloning
Gene:
Dyskeratosis Congenita 1, Dyskerin (DKC1)
Species:
Human
Vector type:
Bacterial Expression Vector
Vector backbone:
pPB-His-GST
Resistance Gene:
Kanamycin
Promoter:
T7 Promoter
Fusion Tag:
His-GST
Expression:
Transient
Catalog No. ABIN4830207
Datasheet
Catalog No. ABIN4830207
Type:
cDNA
Application:
Cloning
Gene:
Dyskeratosis Congenita 1, Dyskerin (DKC1)
Species:
Human
Synonyms:
DKC1, MIR664B, dkc1, dkc1.L, Dkc1, NAP57
Insert length:
1545 bp
Vector type:
Bacterial Expression Vector
Vector backbone:
pPB-His-GST
Resistance Gene:
Kanamycin
Promoter:
T7 Promoter
Fusion Tag:
His-GST
Expression:
Transient
Sequencing Primer:
  • GST Forward primer: 5'-CACGTTTGGTGGTGGCGAC3'
  • T7 terminator primer: 5'-GCTAGTTATTGCTCAGCGG-3'
Format:
Liquid
Buffer:
10 mM Tris-HCI, 1 mM EDTA, pH 8.0
Storage:
-20 °C
  • Type
    • Plasmid
    • Primer
  • Supplier
    • antibodies-online
    • OriGene
    • GenScript
    • ProteoGenix
  • Reactivity
    • Human
    • Rat
    • Mouse
  • Cited in publications
  • Application
    • Protein Expression (PExp)
    • Cloning (Clon)
    • Genome Editing with Engineered Nucleases (GEEN)
    • RNA Interference (RNAi)
  • Conjugate
    • Un-conjugated
    • GFP tag
    • Myc-DYKDDDDK Tag
    • His tag
    • HA tag
    • His-GST
    • His-MBP
    • DYKDDDDK Tag
    • RFP tag
  • Vector Backbone
    • pCMV6-Entry
    • pLenti-U6-sgRNA-PGK-Neo
    • pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
    • pLenti-C-Myc-DDK
    • pLenti-C-mGFP
    • pORF
    • pPB-His-GST
    • pPB-His-MBP
    • pPB-N-His
    • pPM-C-HA
    • pPM-C-His
    • pGFP-C-shLenti
    • pGFP-V-RS
    • pRS
    • pcDNA3.1+C-(K)-DYK
    • pCMV6-AC-GFP
    • pCas-Guide
    • pDONR223
    • pCMV6-AC
    • pCMV6-XL5
    • pRFP-C-RS
  • Vector
    • Mammalian Expression Vector
    • Lentiviral Vector
    • Bacterial Expression Vector
    • Retroviral Vector
    • Cloning Vector
    • Gateway Cloning Vector
  • Insert
    • cDNA
    • ORF
    • shRNA
    • gRNA + Cas9
    • gRNA
  • Type of Oligonucleotide
    • siRNA Oligo
  • Bacterial Resistance
    • Kanamycin
    • Ampicillin
    • Chloramphenicol
    • Spectinomycin
  • Expression Type
    • Transient
    • Stable
  • Selectable Marker
    • Neomycin
    • Puromycin
  • Promoter
    • CMV Promoter
    • U6 Promoter
    • T7 Promoter
    • Enhanced CMV Promoter
    • PGK Promoter
    • SFFV Promoter
  • Format
    • Lyophilized
    • Liquid
    • Viral Particles

Synonyms and alternative names related to DKC1

  • dyskerin pseudouridine synthase 1 (DKC1)
  • microRNA 664b (MIR664B)
  • dyskeratosis congenita 1, dyskerin (dkc1)
  • dyskeratosis congenita 1, dyskerin L homeolog (dkc1.L)
  • dyskeratosis congenita 1, dyskerin (Dkc1)
  • dyskerin pseudouridine synthase 1 (Dkc1)
  • homologue of NAP57 (NAP57)
  • AtCBF5
  • AtNAP57
  • BC068171
  • CBF5
  • cbf5
  • DKC
  • dkc
  • DKC1
  • DKCX
  • dyskerin
  • fv62a07
  • homologue of NAP57
  • NAP57
  • nap57
  • Nap57
  • NOLA4
  • nola4
  • wu:fa28f10
  • wu:fc87a02
  • wu:fi24a05
  • wu:fv62a07
  • XAP101
  • xap101
  • zgc:110395

Gene-IDs for different species

Protein level used designations for DKC1

  • CBF5 homolog
  • H/ACA ribonucleoprotein complex subunit 4
  • cbf5p homolog
  • nopp140-associated protein of 57 kDa
  • nucleolar protein NAP57
  • nucleolar protein family A member 4
  • snoRNP protein DKC1
  • dyskerin
  • fc87a02
  • fi24a05
  • dyskeratosis congenita 1, dyskerin
  • H/ACA ribonucleoprotein complex subunit 4-like
  • h/ACA ribonucleoprotein complex subunit 4-like
  • dyskeratosis congenita 1, dyskerin homolog
Other products related to DKC1 such as antibodies, ELISA kits and high-purity proteins are available on our partner website antibodies-online.com
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