HLA-DRB3 (Major Histocompatibility Complex, Class II, DR beta 3, HLA-DRB3)
Short Description: HLA-DRB3 belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DRA) and a beta (DRB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. DRB1 is expressed at a level five times higher than its paralogues DRB3, DRB4 and DRB5. The presence of DRB3 is linked with allelic variants of DRB1, otherwise it is omitted. There are 4 related pseudogenes: DRB2, DRB6, DRB7, DRB8 and DRB9. [provided by RefSeq, Jul 2008].
More information related to gene HLA-DRB3.
More information related to gene HLA-DRB3.
Products related to HLA-DRB3 Gene:
Recommended next Filters:
21 results :
ORF
Clon
Cloning Vector
pORF
Spectinomycin
unconjugated
Transient
- Type:
- ORF
- Application:
- Cloning
- Gene:
- Major Histocompatibility Complex, Class II, DR beta 3 (HLA-DRB3)
- Species:
- Human
- Vector type:
- Cloning Vector
- Vector backbone:
- pORF
- Resistance Gene:
- Spectinomycin
- Expression:
- Transient
ORF
Clon
Cloning Vector
pORF
Spectinomycin
unconjugated
Transient
- Type:
- ORF
- Application:
- Cloning
- Gene:
- Major Histocompatibility Complex, Class II, DR beta 3 (HLA-DRB3)
- Species:
- Human
- Vector type:
- Cloning Vector
- Vector backbone:
- pORF
- Resistance Gene:
- Spectinomycin
- Expression:
- Transient
cDNA
PExp
Mammalian Expression Vector
pPM-C-HA
Kanamycin
CMV Promoter
HA tag
Stable
- Type:
- cDNA
- Application:
- Protein Expression
- Gene:
- Major Histocompatibility Complex, Class II, DR beta 3 (HLA-DRB3)
- Species:
- Human
- Vector type:
- Mammalian Expression Vector
- Vector backbone:
- pPM-C-HA
- Resistance Gene:
- Kanamycin
- Selection Marker:
- Neomycin
- Promoter:
- CMV Promoter
- Fusion Tag:
- HA tag
- Expression:
- Stable, Transient
cDNA
PExp
Mammalian Expression Vector
pPM-C-HA
Kanamycin
CMV Promoter
HA tag
Stable
- Type:
- cDNA
- Application:
- Protein Expression
- Gene:
- Major Histocompatibility Complex, Class II, DR beta 3 (HLA-DRB3)
- Species:
- Human
- Vector type:
- Mammalian Expression Vector
- Vector backbone:
- pPM-C-HA
- Resistance Gene:
- Kanamycin
- Selection Marker:
- Neomycin
- Promoter:
- CMV Promoter
- Fusion Tag:
- HA tag
- Expression:
- Stable, Transient
gRNA + Cas9
PExp, GEEN
Lentiviral Vector
pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
Ampicillin
U6 Promoter
unconjugated
Stable
- Type:
- gRNA + Cas9
- Application:
- Protein Expression, Genome Editing with Engineered Nucleases
- Gene:
- HLA Class II DR beta 3 (HLA-DRB3)
- NCBI Accession:
- NM_022555
- Species:
- Human
- Vector type:
- Lentiviral Vector
- Vector backbone:
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- Resistance Gene:
- Ampicillin
- Selection Marker:
- Puromycin
- Promoter:
- U6 Promoter, SFFV Promoter
- Expression:
- Stable, Transient
gRNA
PExp, GEEN
Lentiviral Vector
pLenti-U6-sgRNA-PGK-Neo
Ampicillin
U6 Promoter
unconjugated
Stable
- Type:
- gRNA
- Application:
- Protein Expression, Genome Editing with Engineered Nucleases
- Gene:
- Major Histocompatibility Complex, Class II, DR beta 3 (HLA-DRB3)
- NCBI Accession:
- NM_022555
- Species:
- Human
- Vector type:
- Lentiviral Vector
- Vector backbone:
- pLenti-U6-sgRNA-PGK-Neo
- Resistance Gene:
- Ampicillin
- Selection Marker:
- Neomycin
- Promoter:
- U6 Promoter, PGK Promoter
- Expression:
- Stable, Transient
cDNA
Clon
Bacterial Expression Vector
pPB-His-GST
Kanamycin
T7 Promoter
His-GST
Transient
- Type:
- cDNA
- Application:
- Cloning
- Gene:
- Major Histocompatibility Complex, Class II, DR beta 3 (HLA-DRB3)
- Species:
- Human
- Vector type:
- Bacterial Expression Vector
- Vector backbone:
- pPB-His-GST
- Resistance Gene:
- Kanamycin
- Promoter:
- T7 Promoter
- Fusion Tag:
- His-GST
- Expression:
- Transient
cDNA
Clon
Bacterial Expression Vector
pPB-His-GST
Kanamycin
T7 Promoter
His-GST
Transient
- Type:
- cDNA
- Application:
- Cloning
- Gene:
- Major Histocompatibility Complex, Class II, DR beta 3 (HLA-DRB3)
- Species:
- Human
- Vector type:
- Bacterial Expression Vector
- Vector backbone:
- pPB-His-GST
- Resistance Gene:
- Kanamycin
- Promoter:
- T7 Promoter
- Fusion Tag:
- His-GST
- Expression:
- Transient
cDNA
Clon
Bacterial Expression Vector
pPB-N-His
Kanamycin
T7 Promoter
His tag
Transient
- Type:
- cDNA
- Application:
- Cloning
- Gene:
- Major Histocompatibility Complex, Class II, DR beta 3 (HLA-DRB3)
- Species:
- Human
- Vector type:
- Bacterial Expression Vector
- Vector backbone:
- pPB-N-His
- Resistance Gene:
- Kanamycin
- Promoter:
- T7 Promoter
- Fusion Tag:
- His tag
- Expression:
- Transient
cDNA
Clon
Bacterial Expression Vector
pPB-N-His
Kanamycin
T7 Promoter
His tag
Transient
- Type:
- cDNA
- Application:
- Cloning
- Gene:
- Major Histocompatibility Complex, Class II, DR beta 3 (HLA-DRB3)
- Species:
- Human
- Vector type:
- Bacterial Expression Vector
- Vector backbone:
- pPB-N-His
- Resistance Gene:
- Kanamycin
- Promoter:
- T7 Promoter
- Fusion Tag:
- His tag
- Expression:
- Transient
Synonyms and alternative names related to HLA-DRB3
- major histocompatibility complex, class II, DR beta 3 (HLA-DRB3)
- major histocompatibility complex, class II, DRB3 (BOLA-DRB3)
- BLA-DRB3
- Bota-DRB01
- Bota-DRB02
- Bota-DRB04
- Bota-DRB07
- Bota-DRB21
- Bota-DRB22
- HLA-DR3B
- LA-DRB
Gene-IDs for different species
Protein level used designations for HLA-DRB3
- DR7
- HLA class II histocompatibility antigen, DR beta 3 chain
- HLA class II histocompatibility antigen, DRB1-7 beta chain
- MHC class II HLA-DR beta 3 chain
- MHC class II antigen DR beta 3 chain
- MHC class II antigen DRB3
- human leucocyte antigen DRB3
- BoLA-DRB3.2
- DR beta-chain antigen binding domain
- DR-beta chain MHC class II
- MHC class II DR beta chain
- MHC class II DRB3
- MHC class II antigen BoLA-DRB3
- MHC class II antigen beta chain
- MHC class II leukocyte antigen BoLA-DRB3
- MHC(BoLA) class II DR-beta chain
- histocompatibility complex, class II, DR beta 3
- leukocyte antigen DRB3
- major histocompatibility complex class II DR-beta chain
- major histocompatibility complex, class II, DR beta 3
- major histocompatibility complex, class II, DRB3
Proteomics products related to HLA-DRB3 Gene
Other products related to HLA-DRB3 such as antibodies, ELISA kits and high-purity proteins are available on our partner website antibodies-online.com
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